OFLOXIN M

100% Protection And Cure Against Chronic Respiratory Disease (CRD). ENSURING HIGH EFFICACY IN TREATING BACTERIAL INFECTIONS IN POULTRY

OFLOXIN M:

Ofloxacin

A synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a Third - generation fluoroquinolone

Metronidazole

A nitroimidazole antibiotic medication used for anaerobic bacteria and protozoa. Metronidazole is an antibiotic, amebicide, and antiprotozoal!" It is the drug of choice for first episodes of mild-to-moderate Clostridium difficile infection

OFLOXACIN 10% AND METRONIDAZOLE 5% SOLUBLE POWDER. Broad Spectrum FLUOROQUINOLONE with METRONIDAZOLE

Mode of Action

Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, thereby inhibiting bacterial cell division.

Pharmacology

The bioavailability of ofloxacin in the oral form is approximately 96% following oral administration reaching maximum serum concentrations within one to two hours. Between 65% and 80% of an administered oral dose of ofloxacin is excreted unchanged via the kidneys within 48 hours of dosing.

Pharmacokinetics

After multiple-dose administration of 200 mg and 300 mg doses, peak serum levels of 2.2 ug/mL and 3.6 μg/mL.

High (MIC) Values of OFLOXACIN

Minimum inhibitory concentration (MIC,) values of ofloxacin against some of the common isolates of veterinary importance, including Salmonella, are reported to be as low as 0.06 μg/mL (-1) (Greene & Budsberg 1993; Parry et al. 2007).

High Plasma Levels

Comparable plasma levels of ofloxacin (14.76 μg.mL*) have been reported 1 hour after an oral dosage in chickens (Baruah et al.2004), (Gaur et al. 2004).

Short Duration Transfer Rate

Ofloxacin was rapidly transferred as is evident from the short distribution half-life (0.09 h ‡ 0.003 h) and high values of K12/K21 (4.7 h ‡ 0.1 h *) and the K12/K21≥ ratio (3.56 ‡ 0.32).

Large Volumen of Distribution

The large Vdarea (2.48 L.kg ‡ 0.18 L.kg*) measured in chicken indicated extensive distribution of ofloxacin. In accordance with this observation, large volumes of distribution have been reported for ofloxacin and in poultry (1.76 L.kg (-1)).

Good Penetration of OFLOXACIN

Furthermore, a high P/C ratio (4.77 ‡ 0.49) observed in the present study indicated good penetration of the drug.

Elimination of Half-life

The elimination half-life of ofloxacin in the present study was 2.11 h ‡ 0.13 h, which is comparable to that measured in broilers (4.46 h) (Ahmad et al. 2008; Kalaiselvi et al. 2006; Mohan & Garg 2006).

Plasma Binding

The binding of drugs to plasma proteins plays a major role in their distribution, elimination, and therapeutic effectiveness. the extent of plasma protein binding of ofloxacin ranged from 10.76% to 30.4%, with an overall mean of 18.67% ‡ 1.94

Dosage-Poultry

1gm / 1Litre of Drinking Water continuously for 5 Days

Indications

E.coli, Staphylococcus, Streptococcus, Lung Pneumonia, Salmonella, FowlCoryza, Fowl Cholera, and Secondary Bacterial Infection Associated with VVND, IB, and Chick Anemia.