AMOXYL-C

Amoxicillin & Cloxacillin Water Soluble Powder for Poultry

Amoxyl-C

Amoxyl-C is a Synergistic Combination of Broad-spectrum.

Amoxicillin is a Broad-spectrum, bacteriolytic, ß-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other B-lactam antibiotics. Amoxicillin is one of the most common antibiotics prescribed for Poultry.

Amoxicillin is susceptible to degradation by B-lactamase-producing bacteria, which are resistant to a broad spectrum of B-lactam antibiotics, such as penicillin. For this reason, it is often combined with Cloxacillin a B-lactamase inhibitor. This increases effectiveness by reducing its susceptibility to B-lactamase resistance.

Mechanism of Action

Pharmacokinetic Data of Amoxicillin Bio-availability 95% oral Metabolism Less than 30% in liver Half-life 61.3 minutes Excretion Renal

Pharmacokinetic Data of Cloxacillin  Bio-availability 75 to 90% Metabolism 95% Half-life 30 minutes Excretion Renal and Billary

About Cloxacillin

• Cloxacillin is a semisynthetic antibiotic in the same class as penicillin.
• Cloxacillin is used against staphylococci that produce beta-lactamase, due to its large R chain, which does not allow the beta-lactamases to bind.
• Cloxacillin belongs to the class of Penicillinase resistant Penicillins with high spectrum of Antibacterial activity

Advantages of Amoxyl-C

• Feed or Water intake does not affect the absorption.
• Readily absorbed from the G.I. Tract.
• Broad spectrum and Bactericidal in action.
• Beta-lactamase resistant synergistic combination.

Pharmacokinetic differences between Cloxacillin and Di Cloxacillin

Cloxacillin Di-Cloxacillin Application In Poultry Veterinary Since 10 years Never Used anywhere in the world Bio-availability 75-90% 30-50% Absorption from the Gut With or without Feed Empty Gut Destruction due to Acids Highly Acid Stable Fully destroyed Systemic Fully Partially Excretion Renal & Billary Renal Side Effects Nil Higher Incidence of Kidney Damage Synergistic Activity with Amoxicillin Yes No` Enzymatic Conversion to cloxacillin No Converts from Dicloxacillin to Cloxacillin due to Enzymatic action which results in 50% Cloxacillin availability

Composition

• Each 10 gms. Powder Contains Amoxicillin Trihydrate I.P.
• Equivalent to Amoxicillin Base 5% w/w
• Cloxacillin Sodium I.P.
• Equivalent to Cloxacillin Base 5% W/W.

Indications - Poultry

E. coli, Salmonella, Mycoplasma, Coryza, Fowl Cholera, Early Chick, Mortality, Wing Rot, and Dermatitis.

Dosage

AS DIRECTED BY THE VETERINARIAN

Presentation

Store in a cool dry place
Protect from Sunlight.